Jan 1, 2013 · eight studies that evaluated acetaminophen therapy with and without caffeine showed an nnt of 15 in favor of combining acetaminophen with caffeine. If you take too much acetaminophen, get medical help right away. Too much acetaminophen can be very dangerous and cause liver damage. Even if you do not have symptoms, it is important. Caffeine affects adenosine receptors, which are involved in nociception, and plays a significant role in pain regulation.
Sep 27, 2011 · you can take tylenol or ibuprofen, neither has caffeine, and both are over the counter medications. If however, you mean narcotic pain medications, that's a horse of a different colour. Please add whether you mean otc or a prescription medication. In addition, it has vasoconstrictive properties, narrowing blood vessels in the brain.
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